Over the span of his career, Jean-Philippe Wurts has conducted Ensemble Modern, Ensemble Linea, Kammerensemble Neue Musik Berlin, Ensemble Plural, Ensemble Smash, Ensemble Accroche Note, Orchestre National des Pays de Loire, Orchestre National de Bordeaux-Aquitaine, and many others.

His commitment to teaching music has led to regular collaborations with the music schools (Musikhochschulen) of Bremen, Essen, Karlsruhe, in Germany, the Conservatoire National Supérieur de Musique et Danse (National Conservatory of Music and Dance) in Paris, the Haute Ecole des Arts du Rhin, the Strasbourg conservatory and the Eötvös Foundation in Hungary.

As a conductor he has performed many premieres, among them pieces by Klaus Huber, Péter Eötvös, Brian Ferneyhough, Michael Jarrell, Wolfgang Rihm, Younghi Pagh-Paan, Unsuk Chin, Raphaël Cendo, Francesco Filidei, Alberto Posadas, Mark André, Frédéric Durieux, etc.

In September 2015 he was appointed artistic director of the Voix Nouvelles program at the Royaumont Foundation.